In a multicenter clinical test (ISIS-1) performed in 16, 027 patients regarding presumed myocardial infarction, patients providing within 12 hours (mean = 5 hours) after the start of discomfort were randomized to either conventional treatment plus Tenormin (n = 8, 037), or conventional treatment alone (n = 7, 990).No proof of a mutagenic possibility of atenolol was revealed in the dominant dangerous examination (computer mouse), in vivo cytogenetics examination (Chinese hamster) or Ames examination (S typhimurium).

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